Neil McCann had been in charge at Dundee since April 2017
Neil McCann has left his role as Dundee manager with the side bottom of the Scottish Premiership after seven defeats in eight games.
McCann, 44, had been in charge at Dens Park since April 2017.
A run of six straight league losses ended with victory at Hamilton but another defeat followed at home to Kilmarnock on 6 October.
The Dens Park side also lost 3-0 to Championship team Ayr United in the League Cup.
Dundee, who have also relieved assistant manager Graham Gartland of his role, return to league action away to Livingston on Saturday following the international break.
Dundee 'cheated' by 'joke' penalty - McCann
The club said in a statement: "We have explored alternative options to support the management staff recently but unfortunately these did not come to fruition.
"We would like thank Neil and Graham for their efforts while in charge and wish them all the best for the future."
McCann, who had two spells at Dundee as a player, took over from Paul Hartley with the club sitting in the relegation play-off spot and steered them to the safety of 10th in a five-game spell as interim manager.
He then performed a U-turn on his decision to return to his previous role as a television pundit, finishing ninth in his first full season.
Thirteen new players were added to the squad in a major summer overhaul, including Kenny Miller after the veteran striker's brief spell as Livingston player-manager.
But results were disappointing and the side have struggled to find the net so far this term, scoring just five so far in the league.
Source: bbc.com