Tottenham head coach Roberto De Zerbi says defenders Micky van de Ven and Jan Paul van Hecke are available for the Premier League meeting with Manchester United on 10 October.
Pedro Porro and Mykhailo Mudryk will miss the sixth-round fixture because of injuries, while a decision on James Maddison’s involvement will be made closer to kick-off.
Tottenham are bottom of the Premier League, in 20th place, with two points from their opening five matches.