The four players who are key members of the side are battling injuries and will be assessed before the game to ascertain their level of fitness.
Their unavailability will be a source of worry for handler of the side, Kadiri Ikhana who has seen the side struggle to make an impact in the Nigeria Professional Football League this season.
The Ibadan- based side who currently sit in 14 position on the NPFL table have won only twice in the league this season and beat Giwa FC 2-1 in their last home fixture.
Last season, Rivers United were held to a 2-2 draw in Ibadan by 3SC, a result which secured their top flight status.