Liverpool host Villarreal at Anfield at 19:00 GMT, with the English side aiming to maintain its perfect start to the European campaign.
The home team won their opening two matches and will now attempt to make it three victories in a row against a Villarreal side whose form has been inconsistent.
The official starting line-ups have been confirmed.
Liverpool XI: Alisson; Araujo, Jacquet, Van Dijk, Tsimikas; Gravenberch, Mac Allister; Ngumoha, Nyoni, Gakpo; Koumas.
Villarreal XI: Gulacsi; Mourino, Pau Navarro, Renato Veiga, Sergi Cardona; Comesana, Saliba, Pape Gueye, Moleiro; Buchanan, Mikautadze.