Hearts of Oak left Accra on Wednesday night for Tunis ahead of their CAF Confederation Cup match against Esperance.
Coach Herbert Addo led an 18-man squad for the Tunisian capital for the first leg of the ultimate qualifier to be played on Sunday.
Hearts have enjoyed enormous success on the travels in this season’s African campaign.
They however face their sternest test as they come against Esperance who were one of the dropouts of the Champions League.
Hearts will be hoping to secure a favourable result in Tunis to give them the confidence to finish up the tie when they play home in the return leg on June 7.