Champions Asante Kotoko travel to Wa All Stars for their week 5 fixture without talisman Ahmed Toure and three other regulars.
Captain Jordan Opoku, Christopher Bonney and Joseph Addo are also out due to varied reasons.
Striker Toure is out due to ill health and Opoku and goalkeeper Addo are being rested by head coach Mas-Ud Dramani.
Right-back Christopher Bonney picked up an injury during last Friday’s 1-0 win over Inter Allies at home.
The quartet have been replaced by Richard Oti, Abedel Latif, Isaac Amoako and veteran Stephen Oduro.