Ghanaian second-tier side Dunkwa United rallied from behind to beat a 10-man Kotoko 2-1, while rivals Hearts lost by the same margin at Ebusua Dwarfs in an Elite Cup games on Wednesday.
Striker Dauda Mohammed grabbed a brace to help the side with the famous win in front of their home fans after Kwadwo Poku had put the visitors in front.
Defender Ohene Brenya was shown the red card in the second half after he brought down an opponent in the 18-yard box.
Elsewhere in Cape Coast, Hearts of Oak troubles continued with a 2-1 defeat against Ebusua Dwarfs.
The defeat leaves the Accra giants without a win in their last three competitive games.
New Edubiase shared the spoils in a 2-2 draw against current league leaders Ashantigold in a big derby at the Obuasi Len Clay stadium.
Great Olympics posted a 1-0 win over Heart of Lions at the Accra sports stadium.