CAF has appointed referee Hamada el Moussa Nampiandraza of Madagascar to take the centre stage when Ghana play South Africa in a crucial Group C tie at the Estadio de Mongomo on Tuesday.
According to information available to GNA Sports, Cameroonian Evarist Menkoune and Songuifolo Yeo from Ivory Coast, will assists from the lines.
Also on duty when Ghana attempt a win over Bafana Bafana for progress to the last eight would be Janny Sikazwe from Zambia as the fourth official.
Togolese Zoumaro Gnofame is to act as the match commissioner.
Ghana would require a win in any shape to book qualification to the next stage with the Black Stars chasing a fifth Nations Cup glory that spans over three decades.
The Black Stars sit in third place behind Senegal and Algeria with three points from a possible six.