Nigeria champions, Enyimba will hope to do the double over Burundian side, Vital'0 when both teams clash in the second leg of their first leg tie in Bujumbura this weekend.
The Peoples Elephants won the first leg 5-1 last weekend at the Adokiye Amiesimaka Stadium, Port Harcourt in what was unarguably their best performance this season.
The hosts, no doubt, have a mountain to climb as they must score four times without conceding to advance to the second round.
This game offers another chance for Enyimba forward, Mfon Udoh who scored a brace in the first leg win and is now joint top scorer in the competition to prove he is truly back at his best after struggling with injury and loss of form last term.
"The first leg result was a good one for us, but that doesn't mean we will get complacent when we come up against them (Vital'0) in their backyard," the former Akwa United striker told nigeriasoccernet.com on the eve of the team's departure for Burundi.
"We are going to approach the game with all seriousness and hopefully we will come out victorious once again."
Should they make it to the second round as expected, Paul Aigbogun's men will face the winner of the tie between Morocco's Olympique Khourigba and Etoile du Sahel of Tunisia.