Billy Sharp (left) and David McGoldrick have scored 17 of Sheffield United's last 20 goalsFollow live text commentary from 12:45 GMT on Saturday
Sheffield United will be without George Baldock after the right-back injured his calf in the win over Middlesbrough.
Kieron Freeman or Martin Cranie could deputise for Baldock, but Chris Basham is still suspended while Jack O'Connell remains a doubt.
Reading boss Jose Gomes could reward Yakou Meite with a start after impressing in the victory over Blackburn Rovers on Wednesday.
Andy Rinomhota remains a doubt having missed the midweek victory.
Match facts
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Sheffield United have won seven of their last eight league meetings with Reading (D1).
Reading have taken just one point from their last three Championship visits to Bramall Lane against Sheffield United (W0 D1 L2), since a 2-0 win in November 2008.
Sheffield United striker Billy Sharp has been involved in six goals in his last six league starts against Reading (4 goals, 2 assists).
Reading are looking to win consecutive Championship games for the first time since December 2017 - this is their 59th league match since then.
Seventeen of Sheffield United's last 20 league goals have been scored by Billy Sharp (11) or David McGoldrick (6) - the other three have been scored by Mark Duffy, Leon Clarke and Richard Stearman.
Reading have won just two of their last 32 away matches in all competitions (D13 L17).
Source: bbc.com